Se poate administra Neurergin la pacientii cu SIndrom de obosela cronica si insuficienta renala?

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1. Se poate administra Neurergin la pacientii cu SIndrom de obosela cronica si insuficienta renala?
Rasp:
Da, in dozele recomandate ( 1 cp/zi sublingual) se poate administra deoarece eliminarea lui renala a fost studiata in studiile de control toxicologic aferente NADH unde s-a observat ca la doza de 175 mg oral nu au fost raportate reactii adverse. Majoritatea produsilor  de catabolism ai NAD/NADH reintra in ciclul de formare al NAD endogen, creandu-se un proces de " reciclare" a produsilor de catabolism ai NAD/ NADH.

The half-life of NAD+ in mammals is short (up to 10 hours) and the NAD+ pool is used and replenished several times a day.[27,53–58] An estimated 6 to 9 g of NAD+ are required daily to match this constant turnover.[58,59] With this much NAD+ being used, why is the DV so low?
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There’s a large mismatch when comparing the DV (14-16 mg) to the estimated daily turnover (6000-9000 mg). The NAD+-consuming reactions are thought to be the primary reason for high turnover, pointing to the importance of salvaging the NAM that’s leftover from these reactions as a means to maintain healthy NAD+ levels.[6,59] As shown in figure 6, while tryptophan (Trp) and the different niacins (NAM, NA, NR) can generate NAD+, it’s the NAM that’s split off during the consuming reactions that needs to be continuously salvaged and recycled to maintain NAD+ levels. Efficient salvage of NAM allows the body to keep pace with NAD+ turnover.

We use much more NAD+ daily than even mega-dosing of vitamin B3 could keep up with. Most of the NAD+ used by our cells isn’t built from the vitamin B3 we get from food or supplements, it’s rebuilt from recycled NAM."